Monday Night Football: Carolina Panthers vs San Francisco 49ers Preview + Odds

Week 12 ends with a playoff-impacting matchup as the Panthers visit the 49ers in San Francisco. Carolina enters as +7.5 underdogs despite having a shot to take control of the NFC South, while San Francisco gets Brock Purdy and Ricky Pearsall back in the lineup. With both teams motivated and key players returning, this one could be closer than the spread suggests.

Panthers vs. 49ers: A High-Stakes Week 12 Clash in San Francisco

Week 12 wraps up in San Francisco as the Carolina Panthers (6–5) head west to face the 49ers (7–4) in a matchup with major playoff implications. After watching the Buccaneers get dominated by the Rams on Sunday night, Carolina suddenly has a real shot at taking control of the NFC South, if they can pull off a difficult road win. Oddsmakers aren’t convinced, listing the Panthers as +7.5 underdogs, largely due to Brock Purdy’s return after missing nearly six weeks with a toe injury.

Backup Cam Jones held things down respectably, but with Purdy and Ricky Pearsall both returning, the 49ers’ offense looks fully reloaded. With all his weapons healthy again, Purdy is expected to come out firing in his home return. Still, 7.5 points feels like a lot, and this matchup has the potential to be much tighter than the spread suggests. It’s shaping up to be a strong finish to Week 12.

Check out the full game info and betting odds below.

Bet responsively.

Game info

How to watch: ABC | ESPN
Kickoff: 7:15 p.m. EST
Where: Levis Stadium

Week 12	Spread	Moneyline	Total
CAR Panthers	+7.5 (-112)	+310	O 49.5 -110
SF 49ers	-7.5 (-108)	-395	U 49.5 -110

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