Thursday Night Football: Miami Dolphins vs Buffalo Bills Odds + Preview

NFL Week 1 Kickoff: Eagles vs Cowboys

Things aren’t going smoothly for Mike McDaniel in Miami. The Dolphins have stumbled to an 0-2 start in the 2025 season, and the head coach is already feeling the heat from frustrated fans. The road ahead doesn’t get any easier as they travel to face division rival Buffalo Bills, who once again look like legitimate Super Bowl contenders. Miami’s chemistry feels off, and the problems may run deeper than expected heading into Week 3 of the NFL.

Meanwhile, the Bills have been rolling since their dramatic finish against the Baltimore Ravens. Josh Allen looks sharp and healthy, the defense is locked in, and Buffalo is shaping up for another postseason push. Backed by their home crowd at Highmark Stadium, the Bills enter as heavy -850 favorites with a 12.5-point spread. That line might seem a little harsh, but with the Dolphins struggling and on the road, it’s not hard to see why. If this game gets out of hand, it could be McDaniel’s last on the sideline. Still, with the spotlight of primetime and the motivation of a division rivalry, Miami should come ready to fight and keep things closer than the oddsmakers predict. Check out the odds and game info below.

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Game info

How to watch: Prime Video
Kickoff: 7:15 p.m. EST
Where: Highmark Stadium