Thursday Night Football: San Francisco 49ers vs Los Angeles Rams Odds + Preview

Banged up 49ers Team Heads to SoFi Stadium

October is here, even if the weather hasn’t caught up, and the NFL rolls into Week 5 with a matchup that injuries have dimmed. The Los Angeles Rams are playing inspired football, looking more and more like their Super Bowl team from a few years back. They’ll host a battered 49ers squad missing key players on both sides of the ball. With Brock Purdy sidelined, Mac Jones will get the start as an 8.5-point underdog. The line may look steep, but given San Francisco’s injuries, oddsmakers aren’t wrong. Unless the 49ers play inspired ball, it’s hard to see them leaving SoFi with a win. The Rams are poised to dominate and pick up their fourth victory of the season. Check out the full odds and game details below.

Bet responsively.

Game info

How to watch: Prime Video
Kickoff: 7:15 p.m. EST
Where: SoFi Stadium