Thursday Night Football: San Francisco 49ers vs Los Angeles Rams Odds + Preview
Banged up 49ers Team Heads to SoFi Stadium
October is here, even if the weather hasn’t caught up, and the NFL rolls into Week 5 with a matchup that injuries have dimmed. The Los Angeles Rams are playing inspired football, looking more and more like their Super Bowl team from a few years back. They’ll host a battered 49ers squad missing key players on both sides of the ball. With Brock Purdy sidelined, Mac Jones will get the start as an 8.5-point underdog. The line may look steep, but given San Francisco’s injuries, oddsmakers aren’t wrong. Unless the 49ers play inspired ball, it’s hard to see them leaving SoFi with a win. The Rams are poised to dominate and pick up their fourth victory of the season. Check out the full odds and game details below.
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Game info
How to watch: Prime Video
Kickoff: 7:15 p.m. EST
Where: SoFi Stadium
| Week 5 | Spread | Moneyline | Total |
|---|---|---|---|
| SF 49ers | +8.5 (-110) | +340 | O 44.5 -115 |
| LA Rams | -8.5 (-110) | -440 | U 44.5 -105 |