Thursday Night Football: San Francisco 49ers vs Seattle Seahawks Preview + Odds 

The San Francisco 49ers have been struggling this season, largely due to a slew of injuries, and their current 2-3 record reflects that challenge. In Week 6 of the NFL, they’ll take to the road to face the hungry Seattle Seahawks in a highly anticipated Thursday Night Football matchup. This 49ers vs Seahawks TNF preview and odds breakdown highlights the significance of this game for both teams.

Coming off a disappointing loss to the Arizona Cardinals, the 49ers are seeking redemption. Two of their three defeats this season came after the team blew substantial leads, a troubling trend for head coach Kyle Shanahan. Shanahan, who’s faced criticism for his inability to close out games, will need to address these issues quickly if the 49ers hope to stay in the running for a playoff spot. Despite their setbacks, San Francisco remains a team with Super Bowl aspirations, but they need to tighten up their defense and avoid costly mistakes to compete in the highly competitive NFC West.

Meanwhile, the Seattle Seahawks enter this game with momentum, eager to capitalize on the 49ers’ misfortunes. The Seahawks, with a solid record, are looking to extend their lead in the division and prove they can contend with the best teams in the league. With star players on both sides of the ball, this game promises to be an exciting showdown between two NFC West rivals.

Short week for both teams but a great way to kick off Week 6.

Check out the odds below.

Bet responsively.

How to watch | Get Tickets

Week 6 TNFSpreadMoneylineTotal
SF 49ers-3.5 (-110)-192O 49.5 -110
SEA Seahawks+3.5 (-110)+160U 49.5 +110
Odds by Draftkings

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