2025–26 NFL Playoffs: Divisional Round Matchups, Odds & Preview
The 2025–26 NFL Playoffs roll on with a loaded Divisional Round slate following an action-packed Wild Card Weekend. With top seeds entering the mix and high-stakes matchups across both conferences, another thrilling weekend of playoff football is on deck.
The Final Eight: Divisional Round Schedule, Odds & Predictions
The Divisional Round is officially set for the 2025–26 NFL Playoffs, and Wild Card Weekend delivered exactly what fans hoped for—thrilling games and record-setting viewership. The action kicks off with a marquee matchup as the Buffalo Bills, fresh off a hard-fought road win in humid Jacksonville, head to Denver to face rookie quarterback Bo Nix and the Denver Broncos at altitude.
In the NFC, the San Francisco 49ers stunned the defending Super Bowl champions to earn a Divisional Round showdown against the No. 1–seeded Seattle Seahawks. Sunday’s slate keeps the momentum going as the Houston Texans bring their elite defense to Foxborough to take on rookie, MVP candidate Drake Maye and the New England Patriots. The weekend wraps up in frigid conditions at Soldier Field, where the Chicago Bears host the Los Angeles Rams in a primetime clash.
Another unforgettable weekend of playoff football is on deck. Check out the full kickoff times, TV schedule, and odds below.
Update (Jan 17): Divisional Round odds, previews, and game-by-game insights updated through Saturday Game
Bills vs Broncos
Saturday, January 17
Will this be the year Josh Allen finally breaks through? With many of the league’s familiar quarterback roadblocks already eliminated, the opportunity is there, but it won’t come easy. Allen and the Bills head to Mile High as slight +1.5 underdogs, facing a Denver Broncos team led by Sean Payton and an elite defense. Denver’s home-field advantage and defensive pressure will be key factors, especially against a Bills team that has occasionally started slow and been forced to dig out of early deficits. Still, if Allen finds his rhythm early, Buffalo has the firepower to seize control and move one step closer to the Super Bowl. Check out the odds and TV schedule below.
| Kickoff: 3:30 PM ET | CBS | Spread | Moneyline | Total |
|---|---|---|---|
| BUF Bills (12-5) | +1.5 (-112) | +100 | O 45.5 -112 |
| DEN Broncos (14-3) | -1.5 (-108) | -120 | U 45.5 -108 |
Odds as of Jan 17, 2026. Lines subject to change.
49ers vs Seahawks
This matchup is shaping up to be one of the trickiest of the weekend. Sam Darnold is reportedly battling an oblique injury and is listed as questionable heading into the NFC showdown. The San Francisco 49ers aren’t at full strength either, having lost George Kittle to a season-ending Achilles injury while Fred Warner has also been ruled out. Those injuries help explain why San Francisco enters as +7 road underdogs. With both teams dealing with key absences, this game suddenly feels wide open. If Darnold is able to push through the injury, the Seattle Seahawks could have a real path to the NFC Championship. Check out the latest odds below.
| Kickoff: 7: PM ET | FOX | Spread | Moneyline | Total |
|---|---|---|---|
| SF 49ers (12-5) | +7 (-112) | +275 | O 45.5 -102 |
| SEA Seahawks (14-3) | -7 (-108) | -345 | U 45.5 -118 |
Odds as of Jan 17, 2026. Lines subject to change.
Sunday, January 18
Texans (12–5) vs Patriots (14–3)
2:00 PM ET | ESPN
Rams (12–5) vs Bears (11–6)
5:30 PM ET | NBC